4D42
Crystal structure of S. aureus FabI in complex with NADP and 4-fluoro- 5-hexyl-2-phenoxyphenol
Summary for 4D42
Entry DOI | 10.2210/pdb4d42/pdb |
Related | 4D41 4D43 4D44 4D45 4D46 |
Descriptor | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, 4-fluoro-5-hexyl-2-phenoxyphenol, ... (5 entities in total) |
Functional Keywords | short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, safabi, fabi, oxidoreductase |
Biological source | STAPHYLOCOCCUS AUREUS SUBSP. AUREUS N315 |
Total number of polymer chains | 8 |
Total formula weight | 258290.79 |
Authors | Schiebel, J.,Chang, A.,Tonge, P.J.,Sotriffer, C.A.,Kisker, C. (deposition date: 2014-10-26, release date: 2015-03-04, Last modification date: 2023-12-20) |
Primary citation | Schiebel, J.,Chang, A.,Merget, B.,Bommineni, G.R.,Yu, W.,Spagnuolo, L.A.,Baxter, M.V.,Tareilus, M.,Tonge, P.J.,Kisker, C.,Sotriffer, C.A. An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction. Biochemistry, 54:1943-1955, 2015 Cited by PubMed: 25706582DOI: 10.1021/bi5014358 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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