4D38
Structure of bovine endothelial nitric oxide synthase heme domain in complex with (1R,2R)-2-(3-fluorobenzyl)-N-{2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}cyclopropanamine
Summary for 4D38
Entry DOI | 10.2210/pdb4d38/pdb |
Related | 4D2Y 4D2Z 4D30 4D31 4D32 4D33 4D34 4D35 4D36 4D37 4D39 4D3A 4D3B 4V3U 4V3V 4V3W 4V3X 4V3Y 4V3Z |
Descriptor | NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total) |
Functional Keywords | oxidoreductase, nitric oxide synthase, inhibitor complex |
Biological source | BOS TAURUS (CATTLE) |
Cellular location | Cell membrane : P29473 |
Total number of polymer chains | 2 |
Total formula weight | 102211.97 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2014-10-20, release date: 2014-12-24, Last modification date: 2015-03-04) |
Primary citation | Mukherjee, P.,Li, H.,Sevrioukova, I.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58:1067-, 2015 Cited by PubMed: 25489882DOI: 10.1021/JM501719E PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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