4D33

Structure of bovine endothelial nitric oxide synthase heme domain in complex with (N1-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)-N2-(3- fluorophenethyl)ethane-1,2-diamine

4D33 の概要

• エントリーDOI: 10.2210/pdb4d33/pdb
• 関連するPDBエントリー: 4D2Y 4D2Z 4D30 4D31 4D32 4D34 4D35 4D36 4D37 4D38 4D39 4D3A 4D3B 4V3U 4V3V 4V3W 4V3X 4V3Y 4V3Z
• 分子名称: NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (10 entities in total)
• 機能のキーワード: oxidoreductase, nitric oxide synthase, inhibitor complex
• 由来する生物種: BOS TAURUS (CATTLE)
• 細胞内の位置: Cell membrane : P29473
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102424.43

構造登録者

Li, H.,Poulos, T.L. (登録日: 2014-10-20, 公開日: 2014-12-24, 最終更新日: 2015-03-04)

• 主引用文献: Mukherjee, P.,Li, H.,Sevrioukova, I.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase.; J.Med.Chem., 58:1067-, 2015; PubMed: 25489882; DOI: 10.1021/JM501719E

実験手法

X-RAY DIFFRACTION (2.087 Å)