4D31

Structure of rat neuronal nitric oxide synthase heme domain in complex with 2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(3-cyanobenzyl) ethan-1-amine

4D31 の概要

• エントリーDOI: 10.2210/pdb4d31/pdb
• 関連するPDBエントリー: 4D2Y 4D2Z 4D30 4D32 4D33 4D34 4D35 4D36 4D37 4D38 4D39 4D3A 4D3B 4V3U 4V3V 4V3W 4V3X 4V3Y 4V3Z
• 分子名称: NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, nitric oxide synthase, inhibitor complex
• 由来する生物種: RATTUS NORVEGICUS (NORWAY RAT)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100132.72

構造登録者

Li, H.,Poulos, T.L. (登録日: 2014-10-20, 公開日: 2014-12-24, 最終更新日: 2015-03-04)

• 主引用文献: Mukherjee, P.,Li, H.,Sevrioukova, I.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase.; J.Med.Chem., 58:1067-, 2015; PubMed: 25489882; DOI: 10.1021/JM501719E

実験手法

X-RAY DIFFRACTION (1.951 Å)