4D2S

Human TTK in complex with a Dyrk1B inhibitor

Summary for 4D2S

• Entry DOI: 10.2210/pdb4d2s/pdb
• Related: 4D2R
• Descriptor: DUAL SPECIFICITY PROTEIN KINASE TTK, N-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine (3 entities in total)
• Functional Keywords: transferase, oncology
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 33089.01

Authors

Debreczeni, J.E.,Kettle, J.G.,Ballard, P.,Bardelle, C.,Butterworth, S.,Colclough, N.,Critchlow, S.E.,Fairley, G.,Fillery, S.,Graham, M.A.,Goodwin, L.,Guichard, S.,Hudson, K.,Mahmood, A.,Vincent, J.,Ward, R.A.,Whittaker, D. (deposition date: 2014-05-12, release date: 2015-04-22, Last modification date: 2024-05-08)

Primary citation

Kettle, J.G.,Ballard, P.,Bardelle, C.,Cockerill, M.,Colclough, N.,Critchlow, S.E.,Debreczeni, J.E.,Fairley, G.,Fillery, S.,Graham, M.A.,Goodwin, L.,Guichard, S.,Hudson, K.,Ward, R.A.,Whittaker, D.
Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors to Explore a Mek Resistance Hypothesis.
J.Med.Chem., 58:2834-, 2015

PubMed Abstract: Potent and selective inhibitors of Dyrk1B kinase were developed to explore the hypothesis, based on siRNA studies, that Dyrk1B may be a resistance mechanism in cells undergoing a stress response.

PubMed: 25738750
DOI: 10.1021/ACS.JMEDCHEM.5B00098

Experimental method

X-RAY DIFFRACTION (2.5 Å)