4D2S

Human TTK in complex with a Dyrk1B inhibitor

4D2S の概要

• エントリーDOI: 10.2210/pdb4d2s/pdb
• 関連するPDBエントリー: 4D2R
• 分子名称: DUAL SPECIFICITY PROTEIN KINASE TTK, N-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine (3 entities in total)
• 機能のキーワード: transferase, oncology
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33089.01

構造登録者

Debreczeni, J.E.,Kettle, J.G.,Ballard, P.,Bardelle, C.,Butterworth, S.,Colclough, N.,Critchlow, S.E.,Fairley, G.,Fillery, S.,Graham, M.A.,Goodwin, L.,Guichard, S.,Hudson, K.,Mahmood, A.,Vincent, J.,Ward, R.A.,Whittaker, D. (登録日: 2014-05-12, 公開日: 2015-04-22, 最終更新日: 2024-05-08)

主引用文献

Kettle, J.G.,Ballard, P.,Bardelle, C.,Cockerill, M.,Colclough, N.,Critchlow, S.E.,Debreczeni, J.E.,Fairley, G.,Fillery, S.,Graham, M.A.,Goodwin, L.,Guichard, S.,Hudson, K.,Ward, R.A.,Whittaker, D.
Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors to Explore a Mek Resistance Hypothesis.
J.Med.Chem., 58:2834-, 2015

PubMed Abstract: Potent and selective inhibitors of Dyrk1B kinase were developed to explore the hypothesis, based on siRNA studies, that Dyrk1B may be a resistance mechanism in cells undergoing a stress response.

PubMed: 25738750
DOI: 10.1021/ACS.JMEDCHEM.5B00098

実験手法

X-RAY DIFFRACTION (2.5 Å)