4D0B

COMPLEX OF A B21 CHICKEN MHC CLASS I MOLECULE AND A 10MER CHICKEN PEPTIDE

「2YF6」から置き換えられました

4D0B の概要

• エントリーDOI: 10.2210/pdb4d0b/pdb
• 関連するPDBエントリー: 4D0C 4D0D
• 分子名称: MHC CLASS I ANTIGEN, BETA-2-MICROGLOBULIN, PEPTIDE, ... (4 entities in total)
• 機能のキーワード: immune system
• 由来する生物種: GALLUS GALLUS (CHICKEN); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 49092.61

構造登録者

Chappell, P.E.,Roversi, P.,Harrison, M.C.,Mears, L.E.,Kaufman, J.F.,Lea, S.M. (登録日: 2014-04-25, 公開日: 2015-05-06, 最終更新日: 2024-11-13)

主引用文献

Chappell, P.,Meziane, E.K.,Harrison, M.,Magiera, L.,Hermann, C.,Mears, L.,Wrobel, A.G.,Durant, C.,Nielsen, L.L.,Buus, S.,Ternette, N.,Mwangi, W.,Butter, C.,Nair, V.,Ahyee, T.,Duggleby, R.,Madrigal, A.,Roversi, P.,Lea, S.M.,Kaufman, J.
Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding.
Elife, 4:e05345-e05345, 2015

PubMed Abstract: Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell surface expression of class I molecules are inversely correlated in both chickens and humans. This relationship correlates with protective responses against infectious pathogens including Marek's disease virus leading to lethal tumours in chickens and human immunodeficiency virus infection progressing to AIDS in humans. We propose that differences in peptide binding repertoire define two groups of MHC class I molecules strategically evolved as generalists and specialists for different modes of pathogen resistance. We suggest that differences in cell surface expression level ensure the development of optimal peripheral T cell responses. The inverse relationship of peptide repertoire and expression is evidently a fundamental property of MHC molecules, with ramifications extending beyond immunology and medicine to evolutionary biology and conservation.

PubMed: 25860507
DOI: 10.7554/eLife.05345

実験手法

X-RAY DIFFRACTION (2.8 Å)