4CWD

CRYSTAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE,2-OXOGLUTARATE IN COMPLEX WITH 449, A NOVEL SUBSTRATE

4CWD の概要

• エントリーDOI: 10.2210/pdb4cwd/pdb
• 分子名称: GAMMA-BUTYROBETAINE DIOXYGENASE, NICKEL (II) ION, ZINC ION, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, 2-og and iron dependent dioxygenase, carnitine biosynthesis
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: O75936
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45397.47

構造登録者

McDonough, M.A.,Kochan, G.,Rydzik, A.,Schofield, C.J. (登録日: 2014-04-02, 公開日: 2014-09-17, 最終更新日: 2023-12-20)

主引用文献

Rydzik, A.M.,Leung, I.K.,Kochan, G.T.,McDonough, M.A.,Claridge, T.D.,Schofield, C.J.
Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids.
Angew. Chem. Int. Ed. Engl., 53:10925-10927, 2014

PubMed Abstract: γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the final hydroxylation step in the biosynthesis of carnitine. BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products with two or three stereogenic centers.

PubMed: 25164544
DOI: 10.1002/anie.201406125

実験手法

X-RAY DIFFRACTION (1.899 Å)