4CWB

Staphylococcus aureus 7,8-Dihydro-6-hydroxymethylpterin- pyrophosphokinase in complex with AMPCPP and an inhibitor

Summary for 4CWB

Entry DOI	10.2210/pdb4cwb/pdb
Descriptor	7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (6 entities in total)
Functional Keywords	transferase, folate, structure-based drug design
Biological source	STAPHYLOCOCCUS AUREUS
Total number of polymer chains	1
Total formula weight	19297.34
Authors	Dennis, M.L.,Swarbrick, J.D.,Peat, T.S. (deposition date: 2014-04-02, release date: 2015-01-28, Last modification date: 2023-12-20)
Primary citation	Dennis, M.L.,Chhabra, S.,Wang, Z.,Debono, A.,Dolezal, O.,Newman, J.,Pitcher, N.P.,Rahmani, R.,Cleary, B.,Barlow, N.,Hattarki, M.,Graham, B.,Peat, T.S.,Baell, J.B.,Swarbrick, J.D. Structure-Based Design and Development of Functionalized Mercaptoguanine Derivatives as Inhibitors of the Folate Biosynthesis Pathway Enzyme 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase from Staphylococcus Aureus. J.Med.Chem., 57:9612-, 2014 Cited by PubMed: 25357262 DOI: 10.1021/JM501417F PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation