4CTZ
Structure of bovine endothelial nitric oxide synthase heme domain in complex with (S)-6-(2-amino-2-(3-(2-(4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-4-methylpyridin-2-amine
Summary for 4CTZ
Entry DOI | 10.2210/pdb4ctz/pdb |
Related | 4CTP 4CTQ 4CTR 4CTT 4CTU 4CTV 4CTW 4CTX 4CTY 4CU0 4CU1 |
Descriptor | NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total) |
Functional Keywords | oxidoreductase, inhibitor complex |
Biological source | BOS TAURUS (CATTLE) |
Cellular location | Cell membrane : P29473 |
Total number of polymer chains | 2 |
Total formula weight | 102348.20 |
Authors | Chreifi, G.,Li, H.,Poulos, T.L. (deposition date: 2014-03-15, release date: 2014-05-07, Last modification date: 2014-12-03) |
Primary citation | Kang, S.,Tang, W.,Li, H.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Nitric Oxide Synthase Inhibitors that Interact with Both a Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity. J.Med.Chem., 57:4382-, 2014 Cited by PubMed: 24758147DOI: 10.1021/JM5004182 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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