4CTX

Structure of rat neuronal nitric oxide synthase heme domain in complex with (S)-6-(3-amino-2-(5-(2-(6-amino-4-methylpyridin-2-yl) ethyl)pyridin-3-yl)propyl)-4-methylpyridin-2-amine

Summary for 4CTX

Related4CTP 4CTQ 4CTR 4CTT 4CTU 4CTV 4CTW 4CTY 4CTZ 4CU0 4CU1
DescriptorNITRIC OXIDE SYNTHASE, BRAIN, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total)
Functional Keywordsoxidoreductase, inhibitor complex
Biological sourceRATTUS NORVEGICUS (NORWAY RAT)
Cellular locationCell membrane, sarcolemma; Peripheral membrane protein (By similarity) P29476
Total number of polymer chains2
Total molecular weight100277.02
Authors
Li, H.,Poulos, T.L. (deposition date: 2014-03-15, release date: 2014-05-07, Last modification date: 2014-06-04)
Primary citation
Kang, S.,Tang, W.,Li, H.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.
Nitric Oxide Synthase Inhibitors that Interact with Both a Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity.
J.Med.Chem., 57:4382-, 2014
PubMed: 24758147 (PDB entries with the same primary citation)
DOI: 10.1021/JM5004182
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.82 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22770.1%4.4%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution