4CT3

Methylmercury chloride derivative structure of the lytic CHAPK domain of the endolysin LysK from Staphylococcus aureus bacteriophage K

4CT3 の概要

• エントリーDOI: 10.2210/pdb4ct3/pdb
• 関連するPDBエントリー: 4CSH
• 分子名称: ORF30/ORF32, CHLORIDE ION, GLYCEROL, ... (8 entities in total)
• 機能のキーワード: viral protein, peptidoglycan, protease
• 由来する生物種: Kayvirus kay
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 79598.92

構造登録者

Sanz-Gaitero, M.,Keary, R.,Garcia-Doval, C.,Coffey, A.,van Raaij, M.J. (登録日: 2014-03-12, 公開日: 2014-08-06, 最終更新日: 2024-11-20)

主引用文献

Sanz-Gaitero, M.,Keary, R.,Garcia-Doval, C.,Coffey, A.,van Raaij, M.J.
Crystal structure of the lytic CHAP(K) domain of the endolysin LysK from Staphylococcus aureus bacteriophage K.
Virol. J., 11:133-133, 2014

PubMed Abstract: Bacteriophages encode endolysins to lyse their host cell and allow escape of their progeny. Endolysins are also active against Gram-positive bacteria when applied from the outside and are thus attractive anti-bacterial agents. LysK, an endolysin from staphylococcal phage K, contains an N-terminal cysteine-histidine dependent amido-hydrolase/peptidase domain (CHAP(K)), a central amidase domain and a C-terminal SH3b cell wall-binding domain. CHAP(K) cleaves bacterial peptidoglycan between the tetra-peptide stem and the penta-glycine bridge.

PubMed: 25064136
DOI: 10.1186/1743-422X-11-133

実験手法

X-RAY DIFFRACTION (1.69 Å)