4CQF
Crystal structure of Schistosoma mansoni HDAC8 complexed with a mercaptoacetamide inhibitor
Summary for 4CQF
| Entry DOI | 10.2210/pdb4cqf/pdb |
| Descriptor | HISTONE DEACETYLASE 8, ZINC ION, POTASSIUM ION, ... (7 entities in total) |
| Functional Keywords | hydrolase, structural protein, eukaryotes, platyhelminths, epigenetics, histone deacetylases, inhibition |
| Biological source | SCHISTOSOMA MANSONI |
| Total number of polymer chains | 4 |
| Total formula weight | 204924.16 |
| Authors | Marek, M.,Romier, C. (deposition date: 2014-02-14, release date: 2014-04-02, Last modification date: 2023-12-20) |
| Primary citation | Stolfa, D.A.,Marek, M.,Lancelot, J.,Hauser, A.T.,Walter, A.,Leproult, E.,Melesina, J.,Rumpf, T.,Wurtz, J.M.,Cavarelli, J.,Sippl, W.,Pierce, R.J.,Romier, C.,Jung, M. Molecular Basis for the Anti-Parasitic Activity of a Mercaptoacetamide Derivative that Inhibits Histone Deacetylase 8 (Hdac8) from the Human Pathogen Schistosoma Mansoni J.Mol.Biol., 426:3442-, 2014 Cited by PubMed: 24657767DOI: 10.1016/J.JMB.2014.03.007 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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