4COX

CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, INDOMETHACIN

4COX の概要

• エントリーDOI: 10.2210/pdb4cox/pdb
• 分子名称: CYCLOOXYGENASE-2, 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
• 機能のキーワード: peroxidase, dioxygenase, cyclooxygenase, nonsteroidal antiinflammatory drugs, inflammation, arthritis, prostaglandin, prostaglandin synthase, oxidoreductase
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 275826.47

構造登録者

Kurumbail, R.,Stallings, W. (登録日: 1996-12-18, 公開日: 1997-12-24, 最終更新日: 2023-08-09)

• 主引用文献: Kurumbail, R.G.,Stevens, A.M.,Gierse, J.K.,McDonald, J.J.,Stegeman, R.A.,Pak, J.Y.,Gildehaus, D.,Miyashiro, J.M.,Penning, T.D.,Seibert, K.,Isakson, P.C.,Stallings, W.C.; Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.; Nature, 384:644-648, 1996; PubMed: 8967954; DOI: 10.1038/384644a0

実験手法

X-RAY DIFFRACTION (2.9 Å)