4CN9

structure of proximal thread matrix protein 1 (PTMP1) from the mussel byssus with zinc occupied MIDAS motif

4CN9 の概要

• エントリーDOI: 10.2210/pdb4cn9/pdb
• 関連するPDBエントリー: 4CN8 4CNB
• 分子名称: PROXIMAL THREAD MATRIX PROTEIN 1, ZINC ION, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: structural protein
• 由来する生物種: MYTILUS GALLOPROVINCIALIS (MEDITERRANEAN MUSSEL)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98949.01

構造登録者

Gertz, M.,Suhre, M.H.,Scheibel, T.,Steegborn, C. (登録日: 2014-01-21, 公開日: 2014-03-12, 最終更新日: 2024-11-13)

主引用文献

Suhre, M.H.,Gertz, M.,Steegborn, C.,Scheibel, T.
Structural and Functional Features of a Collagen-Binding Matrix Protein from the Mussel Byssus.
Nat.Commun., 5:3392-, 2014

PubMed Abstract: Blue mussels adhere to surfaces by the byssus, a holdfast structure composed of individual threads representing a collagen fibre reinforced composite. Here, we present the crystal structure and function of one of its matrix proteins, the proximal thread matrix protein 1, which is present in the proximal section of the byssus. The structure reveals two von Willebrand factor type A domains linked by a two-β-stranded linker yielding a novel structural arrangement. In vitro, the protein binds heterologous collagens with high affinity and affects collagen assembly, morphology and arrangement of its fibrils. By providing charged surface clusters as well as insufficiently coordinated metal ions, the proximal thread matrix protein 1 might interconnect other byssal proteins and thereby contribute to the integrity of the byssal threads in vivo. Moreover, the protein could be used for adjusting the mechanical properties of collagen materials, a function likely important in the natural byssus.

PubMed: 24569701
DOI: 10.1038/NCOMMS4392

実験手法

X-RAY DIFFRACTION (1.9 Å)