4CK8
STEROL 14-ALPHA DEMETHYLASE (CYP51)FROM TRYPANOSOMA CRUZI IN COMPLEX WITH (R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl 4-(4-(3,4- dichlorophenyl)piperazin-1-yl)phenylcarbamate (LFD)
Summary for 4CK8
Entry DOI | 10.2210/pdb4ck8/pdb |
Related | 4CK9 4CKA |
Descriptor | STEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, (1R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl {4-[4-(3,4-dichlorophenyl)piperazin-1-yl]phenyl}carbamate, ... (4 entities in total) |
Functional Keywords | cytochrome p450, oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane |
Biological source | TRYPANOSOMA CRUZI |
Cellular location | Membrane; Single-pass membrane protein (Potential): Q7Z1V1 |
Total number of polymer chains | 2 |
Total formula weight | 107549.45 |
Authors | Friggeri, L.,Wawrzak, Z.,Tortorella, S.,Lepesheva, G.I. (deposition date: 2013-12-30, release date: 2014-07-30, Last modification date: 2023-12-20) |
Primary citation | Friggeri, L.,Hargrove, T.Y.,Rachakonda, G.,Williams, A.D.,Wawrzak, Z.,Di Santo, R.,De Vita, D.,Waterman, M.R.,Tortorella, S.,Villalta, F.,Lepesheva, G.I. Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma Cruzi Sterol 14Alpha-Demethylase: Two Regions of the Enzyme Molecule Potentiate its Inhibition. J.Med.Chem., 57:6704-, 2014 Cited by PubMed: 25033013DOI: 10.1021/JM500739F PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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