4CK8

STEROL 14-ALPHA DEMETHYLASE (CYP51)FROM TRYPANOSOMA CRUZI IN COMPLEX WITH (R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl 4-(4-(3,4- dichlorophenyl)piperazin-1-yl)phenylcarbamate (LFD)

4CK8 の概要

• エントリーDOI: 10.2210/pdb4ck8/pdb
• 関連するPDBエントリー: 4CK9 4CKA
• 分子名称: STEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, (1R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl {4-[4-(3,4-dichlorophenyl)piperazin-1-yl]phenyl}carbamate, ... (4 entities in total)
• 機能のキーワード: cytochrome p450, oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane
• 由来する生物種: TRYPANOSOMA CRUZI
• 細胞内の位置: Membrane; Single-pass membrane protein (Potential): Q7Z1V1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 107549.45

構造登録者

Friggeri, L.,Wawrzak, Z.,Tortorella, S.,Lepesheva, G.I. (登録日: 2013-12-30, 公開日: 2014-07-30, 最終更新日: 2023-12-20)

• 主引用文献: Friggeri, L.,Hargrove, T.Y.,Rachakonda, G.,Williams, A.D.,Wawrzak, Z.,Di Santo, R.,De Vita, D.,Waterman, M.R.,Tortorella, S.,Villalta, F.,Lepesheva, G.I.; Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma Cruzi Sterol 14Alpha-Demethylase: Two Regions of the Enzyme Molecule Potentiate its Inhibition.; J.Med.Chem., 57:6704-, 2014; PubMed: 25033013; DOI: 10.1021/JM500739F

実験手法

X-RAY DIFFRACTION (2.62 Å)