4CK4

Ovine beta-Lactoglobulin at Atomic Resolution

4CK4 の概要

• エントリーDOI: 10.2210/pdb4ck4/pdb
• 分子名称: BETA_LACTOGLOBULIN-1/B, SULFATE ION, AMMONIUM ION, ... (7 entities in total)
• 機能のキーワード: transport protein, ovine-lactoglobulin, high resolution
• 由来する生物種: OVIS ARIES (SHEEP)
• 細胞内の位置: Secreted: P67976
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37263.47

構造登録者

Kontopidis, G.,Nordle, A.,Sawyer, L. (登録日: 2013-12-27, 公開日: 2014-10-08, 最終更新日: 2024-11-13)

主引用文献

Kontopidis, G.,Nordle Gilliver, A.,Sawyer, L.
Ovine Beta-Lactoglobulin at Atomic Resolution
Acta Crystallogr.,Sect.F, 70:1498-, 2014

PubMed Abstract: The crystal structure of the triclinic form of the milk protein β-lactoglobulin from sheep (Ovis aries) at 1.1 Å resolution is described together with a comparison of the triclinic structures of the low-pH bovine and high-pH ovine proteins. All three structures are remarkably similar, despite the well known pH-dependent conformational transition described for the bovine and porcine proteins that occurs in solution. The high resolution of the present structure determination has allowed a more accurate description of the protein than has hitherto been possible, but it is still not clear whether flexibility changes in the external loops can compensate for the presence of a significant void in the unliganded interior of the structure.

PubMed: 25372816
DOI: 10.1107/S2053230X14020950

実験手法

X-RAY DIFFRACTION (1.12 Å)