4CIL

YopM-InlB: Hybrid leucine-rich repeat protein

4CIL の概要

• エントリーDOI: 10.2210/pdb4cil/pdb
• 分子名称: YOPM-CAP, INTERNALIN B (2 entities in total)
• 機能のキーワード: signaling protein, capping, fusion protein, lrr, protein chimera, protein design, protein engineering
• 由来する生物種: YERSINIA ENTEROCOLITICA; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32170.66

構造登録者

Breitsprecher, D.,Niemann, H.H. (登録日: 2013-12-11, 公開日: 2014-04-02, 最終更新日: 2023-12-20)

主引用文献

Breitsprecher, D.,Gherardi, E.,Bleymuller, W.M.,Niemann, H.H.
Crystal Structure of an Engineered Yopm-Inlb Hybrid Protein.
Bmc Struct.Biol., 14:12-, 2014

PubMed Abstract: The multi-domain protein InlB (internalin B) from Listeria monocytogenes is an agonist of the human receptor tyrosine kinase MET. Only the internalin domain directly interacts with MET. The internalin domain consists of seven central leucine-rich repeats (LRRs) flanked by an N-terminal helical cap domain and a C-terminal immunoglobulin-like structure. A potential function of the N-terminal cap in receptor binding could so far not be demonstrated by deleting the cap, since the cap is also implicated in nucleating folding of the LRR domain.

PubMed: 24669959
DOI: 10.1186/1472-6807-14-12

実験手法

X-RAY DIFFRACTION (1.5 Å)