4CGM

Leishmania major N-myristoyltransferase in complex with a biphenyl- derivative inhibitor

4CGM の概要

• エントリーDOI: 10.2210/pdb4cgm/pdb
• 関連するPDBエントリー: 4CGL 4CGN 4CGO 4CGP
• 分子名称: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, N-[[3-[3-(6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-ylmethyl)phenyl]phenyl]methyl]-2-pyridin-3-yl-ethanamine, ... (5 entities in total)
• 機能のキーワード: transferase, myristoylation
• 由来する生物種: LEISHMANIA MAJOR
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48952.93

構造登録者

Brannigan, J.A.,Roberts, S.M.,Bell, A.S.,Hutton, J.A.,Smith, D.F.,Tate, E.W.,Leatherbarrow, R.J.,Wilkinson, A.J. (登録日: 2013-11-25, 公開日: 2014-07-09, 最終更新日: 2014-08-13)

• 主引用文献: Brannigan, J.A.,Roberts, S.M.,Bell, A.S.,Hutton, J.A.,Hodgkinson, M.R.,Tate, E.W.,Leatherbarrow, R.J.,Smith, D.F.,Wilkinson, A.J.; Diverse Modes of Binding in Structures of Leishmania Major N-Myristoyltransferase with Selective Inhibitors; Iucrj, 1:250-, 2014; PubMed: 25075346; DOI: 10.1107/S2052252514013001

実験手法

X-RAY DIFFRACTION (1.7 Å)