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4CFU

Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.

Summary for 4CFU
Entry DOI10.2210/pdb4cfu/pdb
Related4CFM 4CFN 4CFV 4CFW 4CFX
DescriptorCYCLIN-DEPENDENT KINASE 2, CYCLIN-A2, 3-[2-azanyl-6-(cyclohexylmethoxy)-7H-purin-8-yl]-2-methyl-benzoic acid, ... (6 entities in total)
Functional Keywordstransferase, structure-based drug design, conformational restraint, reversed binding mode
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Nucleus : P20248 P20248
Total number of polymer chains4
Total formula weight129807.53
Authors
Primary citationCarbain, B.,Paterson, D.J.,Anscombe, E.,Campbell-Dexter, A.,Cano, C.,Echalier, A.,Endicott, J.,Golding, B.T.,Haggerty, K.,Hardcastle, I.R.,Jewsbury, P.J.,Newell, D.R.,Noble, M.,Roche, C.,Wang, L.,Griffin, R.J.
8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode.
J.Med.Chem., 57:56-, 2014
Cited by
PubMed: 24304238
DOI: 10.1021/JM401555V
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

数据于2024-03-27公开中

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