4CFF
Structure of full length human AMPK in complex with a small molecule activator, a thienopyridone derivative (A-769662)
Summary for 4CFF
Entry DOI | 10.2210/pdb4cff/pdb |
Related | 4CFE 4CFH |
Descriptor | 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ... (6 entities in total) |
Functional Keywords | transferase, nucleotide-binding, staurosporine-binding, serine/threonine-protein kinase, activator, carbohydrate binding module (cbm) |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 6 |
Total formula weight | 272494.16 |
Authors | Xiao, B.,Sanders, M.J.,Carmena, D.,Bright, N.J.,Haire, L.F.,Underwood, E.,Patel, B.R.,Heath, R.B.,Walker, P.A.,Hallen, S.,Giordanetto, F.,Martin, S.R.,Carling, D.,Gamblin, S.J. (deposition date: 2013-11-14, release date: 2013-12-25, Last modification date: 2023-12-20) |
Primary citation | Xiao, B.,Sanders, M.J.,Carmena, D.,Bright, N.J.,Haire, L.F.,Underwood, E.,Patel, B.R.,Heath, R.B.,Walker, P.A.,Hallen, S.,Giordanetto, F.,Martin, S.R.,Carling, D.,Gamblin, S.J. Structural Basis of Ampk Regulation by Small Molecule Activators. Nat.Commun., 4:3017-, 2013 Cited by PubMed: 24352254DOI: 10.1038/NCOMMS4017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.924 Å) |
Structure validation
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