4CDF

Human DPP1 in complex with (2S,4S)-N-((1S)-1-cyano-2-(4-(4- cyanophenyl)phenyl)ethyl)-4-hydroxy-piperidine-2-carboxamide

Summary for 4CDF

• Entry DOI: 10.2210/pdb4cdf/pdb
• Related: 4CDC 4CDD 4CDE
• Descriptor: DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN, DIPEPTIDYL PEPTIDASE 1 HEAVY CHAIN, DIPEPTIDYL PEPTIDASE 1 LIGHT CHAIN, ... (7 entities in total)
• Functional Keywords: hydrolase, inhibitor
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 6
• Total formula weight: 81564.41

Authors

Debreczeni, J.,Edman, K.,Furber, M.,Tiden, A.,Gardiner, P.,Mete, T.,Ford, R.,Millichip, I.,Stein, L.,Mather, A.,Kinchin, E.,Luckhurst, C.,Cage, P.,Sanghanee, H.,Breed, J.,Wissler, L. (deposition date: 2013-10-31, release date: 2014-03-19, Last modification date: 2024-10-23)

Primary citation

Furber, M.,Gardiner, P.,Tiden, A.K.,Mete, A.,Ford, R.,Millichip, I.,Stein, L.,Mather, A.,Kinchin, E.,Luckhurst, C.,Barber, S.,Cage, P.,Sanganee, H.,Austin, R.,Chohan, K.,Beri, R.,Thong, B.,Wallace, A.,Oreffo, V.,Hutchinson, R.,Harper, S.,Debreczeni, J.,Breed, J.,Wissler, L.,Edman, K.
Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate.
J.Med.Chem., 57:2357-, 2014

PubMed Abstract: A lead generation and optimization program delivered the highly selective and potent CatC inhibitor 10 as an in vivo tool compound and potential development candidate. Structural studies were undertaken to generate SAR understanding.

PubMed: 24592859
DOI: 10.1021/JM401705G

Experimental method

X-RAY DIFFRACTION (2.2 Å)