4CBY
Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease
4CBY の概要
エントリーDOI | 10.2210/pdb4cby/pdb |
関連するPDBエントリー | 4CBT |
分子名称 | HISTONE DEACETYLASE 4, (1R,2R,3R)-2-[4-(1,3-oxazol-5-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide, ZINC ION, ... (5 entities in total) |
機能のキーワード | hydrolase, neurodegeneration, amyotrophic lateral sclerosis, muscle atrophy, class iia histone deacetylase inhibitors, sar, hydroxamic acid, cyclopropanation |
由来する生物種 | HOMO SAPIENS (HUMAN) |
細胞内の位置 | Nucleus: P56524 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 173010.80 |
構造登録者 | Burli, R.W.,Luckhurst, C.A.,Aziz, O.,Matthews, K.L.,Yates, D.,Lyons, K.A.,Beconi, M.,McAllister, G.,Breccia, P.,Stott, A.J.,Penrose, S.D.,Wall, M.,Lamers, M.,Leonard, P.,Mueller, I.,Richardson, C.M.,Jarvis, R.,Stones, L.,Hughes, S.,Wishart, G.,Haughan, A.F.,O'Connell, C.,Mead, T.,McNeil, H.,Vann, J.,Mangette, J.,Maillard, M.,Beaumont, V.,Munoz-Sanjuan, I.,Dominguez, C. (登録日: 2013-10-17, 公開日: 2013-12-11, 最終更新日: 2024-05-08) |
主引用文献 | Burli, R.W.,Luckhurst, C.A.,Aziz, O.,Matthews, K.L.,Yates, D.,Lyons, K.A.,Beconi, M.,McAllister, G.,Breccia, P.,Stott, A.J.,Penrose, S.D.,Wall, M.,Lamers, M.,Leonard, P.,Muller, I.,Richardson, C.M.,Jarvis, R.,Stones, L.,Hughes, S.,Wishart, G.,Haughan, A.F.,O'Connell, C.,Mead, T.,McNeil, H.,Vann, J.,Mangette, J.,Maillard, M.,Beaumont, V.,Munoz-Sanjuan, I.,Dominguez, C. Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. J. Med. Chem., 56:9934-9954, 2013 Cited by PubMed: 24261862DOI: 10.1021/jm4011884 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.72 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード