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4CBT

Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease

4CBT の概要
エントリーDOI10.2210/pdb4cbt/pdb
関連するPDBエントリー4CBY
分子名称HISTONE DEACETYLASE 4, (1R,2R,3R)-2-[4-(5-fluoranylpyrimidin-2-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide, ZINC ION, ... (4 entities in total)
機能のキーワードhydrolase, neurodegeneration, huntingtons disease, amyotrophic lateral sclerosis, muscle atrophy, class iia histone deacetylase inhibitors, sar, hydroxamic acid, cyclopropanation
由来する生物種HOMO SAPIENS (HUMAN)
細胞内の位置Nucleus: P56524
タンパク質・核酸の鎖数3
化学式量合計129833.44
構造登録者
主引用文献Burli, R.W.,Luckhurst, C.A.,Aziz, O.,Matthews, K.L.,Yates, D.,Lyons, K.A.,Beconi, M.,McAllister, G.,Breccia, P.,Stott, A.J.,Penrose, S.D.,Wall, M.,Lamers, M.,Leonard, P.,Muller, I.,Richardson, C.M.,Jarvis, R.,Stones, L.,Hughes, S.,Wishart, G.,Haughan, A.F.,O'Connell, C.,Mead, T.,McNeil, H.,Vann, J.,Mangette, J.,Maillard, M.,Beaumont, V.,Munoz-Sanjuan, I.,Dominguez, C.
Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
J. Med. Chem., 56:9934-9954, 2013
Cited by
PubMed: 24261862
DOI: 10.1021/jm4011884
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (3.03 Å)
構造検証レポート
Validation report summary of 4cbt
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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