4CA4

Crystal structure of FimH lectin domain with the Tyr48Ala mutation, in complex with heptyl alpha-D-mannopyrannoside

4CA4 の概要

• エントリーDOI: 10.2210/pdb4ca4/pdb
• 分子名称: FIMH, heptyl alpha-D-mannopyranoside (3 entities in total)
• 機能のキーワード: cell adhesion, bacterial adhesin, type 1 fimbriae, urinary tract infection, variable immunoglobulin fold, heptyl mannose, fimh antagonist
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34206.14

構造登録者

Rabbani, S.,Bouckaert, J.,Zalewski, A.,Preston, R.,Eid, S.,Thompson, A.,Puorger, C.,Glockshuber, R.,Ernst, B. (登録日: 2013-10-06, 公開日: 2014-10-29, 最終更新日: 2023-12-20)

• 主引用文献: Rabbani, S.,Krammer, E.M.,Roos, G.,Zalewski, A.,Preston, R.,Eid, S.,Zihlmann, P.,Prevost, M.,Lensink, M.F.,Thompson, A.,Ernst, B.,Bouckaert, J.; Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding.; IUCrJ, 4:7-23, 2017; PubMed: 28250938; DOI: 10.1107/S2052252516016675

実験手法

X-RAY DIFFRACTION (2.84 Å)