4C51

Crystal Structure of the Catalase-Peroxidase (KatG) R418L mutant from Mycobacterium Tuberculosis

4C51 の概要

• エントリーDOI: 10.2210/pdb4c51/pdb
• 関連するPDBエントリー: 4C50
• 分子名称: CATALASE-PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, alpha-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS H37RV
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 162880.43

構造登録者

Hersleth, H.-P.,Zhao, X.,Magliozzo, R.S.,Andersson, K.K. (登録日: 2013-09-10, 公開日: 2013-11-13, 最終更新日: 2023-12-20)

主引用文献

Zhao, X.,Hersleth, H.P.,Zhu, J.,Andersson, K.K.,Magliozzo, R.S.
Access Channel Residues Ser315 and Asp137 in Mycobacterium Tuberculosis Catalase-Peroxidase (Katg) Control Peroxidatic Activation of the Pro-Drug Isoniazid.
Chem.Commun.(Camb.), 49:11650-, 2013

PubMed Abstract: Peroxidatic activation of the anti-tuberculosis pro-drug isoniazid by Mycobacterium tuberculosis catalase-peroxidase (KatG) is regulated by gating residues of a heme access channel. The steric restriction at the bottleneck of this channel is alleviated by replacement of residue Asp137 with Ser, according to crystallographic and kinetic studies.

PubMed: 24185282
DOI: 10.1039/C3CC47022A

実験手法

X-RAY DIFFRACTION (3.1 Å)