4BYJ

Aurora A kinase bound to a highly selective imidazopyridine inhibitor

4BYJ の概要

• エントリーDOI: 10.2210/pdb4byj/pdb
• 関連するPDBエントリー: 4BYI
• 分子名称: AURORA KINASE A, (S)-N-(1-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-3-yl)acetamide (2 entities in total)
• 機能のキーワード: transferase, cell cycle, inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O14965
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33322.62

構造登録者

Joshi, A.,Kosmopoulou, M.,Bayliss, R. (登録日: 2013-07-19, 公開日: 2013-11-20, 最終更新日: 2023-12-20)

• 主引用文献: Bavetsias, V.,Faisal, A.,Crumpler, S.,Brown, N.,Kosmopoulou, M.,Joshi, A.,Atrash, B.,Perez-Fuertes, Y.,Schmitt, J.A.,Boxall, K.J.,Burke, R.,Sun, C.,Avery, S.,Bush, K.,Henley, A.,Raynaud, F.I.,Workman, P.,Bayliss, R.,Linardopoulos, S.,Blagg, J.; Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells.; J.Med.Chem., 56:9122-, 2013; PubMed: 24195668; DOI: 10.1021/JM401115G

実験手法

X-RAY DIFFRACTION (2.75 Å)