4BUL

Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

Summary for 4BUL

• Entry DOI: 10.2210/pdb4bul/pdb
• Descriptor: DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A, 5'-D(*TP*GP*TP*GP*CP*GP*GP*TP*GP*TP*AP*CP*CP*TP *AP*CP*GP*GP*CP*T)-3', 5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*AP*CP *CP*GP*CP*AP*C)-3', ... (6 entities in total)
• Functional Keywords: isomerase, type iia topoisomerases, nbtis
• Biological source: STAPHYLOCOCCUS AUREUS; More
• Cellular location: Cytoplasm : Q99XG5
• Total number of polymer chains: 6
• Total formula weight: 181445.11

Authors

Miles, T.J.,Hennessy, A.J.,Bax, B.,Brooks, G.,Brown, B.S.,Brown, P.,Cailleau, N.,Chen, D.,Dabbs, S.,Davies, D.T.,Esken, J.M.,Giordano, I.,Hoover, J.L.,Huang, J.,Jones, G.E.,Sukmar, S.K.K.,Spitzfaden, C.,Markwell, R.E.,Minthorn, E.A.,Rittenhouse, S.,Gwynn, M.N.,Pearson, N.D. (deposition date: 2013-06-20, release date: 2013-08-07, Last modification date: 2023-12-20)

• Primary citation: Miles, T.J.,Hennessy, A.J.,Bax, B.,Brooks, G.,Brown, B.S.,Brown, P.,Cailleau, N.,Chen, D.,Dabbs, S.,Davies, D.T.,Esken, J.M.,Giordano, I.,Hoover, J.L.,Huang, J.,Jones, G.E.,Kusalakumari Sukmar, S.K.,Spitzfaden, C.,Markwell, R.E.,Minthorn, E.A.,Rittenhouse, S.,Gwynn, M.N.,Pearson, N.D.; Novel Hydroxyl Tricyclics (E.G., Gsk966587) as Potent Inhibitors of Bacterial Type Iia Topoisomerases.; Bioorg.Med.Chem.Lett., 23:5437-, 2013; PubMed: 23968823; DOI: 10.1016/J.BMCL.2013.07.013

Experimental method

X-RAY DIFFRACTION (2.6 Å)