4BUL

Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

4BUL の概要

• エントリーDOI: 10.2210/pdb4bul/pdb
• 分子名称: DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A, 5'-D(*TP*GP*TP*GP*CP*GP*GP*TP*GP*TP*AP*CP*CP*TP *AP*CP*GP*GP*CP*T)-3', 5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*AP*CP *CP*GP*CP*AP*C)-3', ... (6 entities in total)
• 機能のキーワード: isomerase, type iia topoisomerases, nbtis
• 由来する生物種: STAPHYLOCOCCUS AUREUS; 詳細
• 細胞内の位置: Cytoplasm : Q99XG5
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 181445.11

構造登録者

Miles, T.J.,Hennessy, A.J.,Bax, B.,Brooks, G.,Brown, B.S.,Brown, P.,Cailleau, N.,Chen, D.,Dabbs, S.,Davies, D.T.,Esken, J.M.,Giordano, I.,Hoover, J.L.,Huang, J.,Jones, G.E.,Sukmar, S.K.K.,Spitzfaden, C.,Markwell, R.E.,Minthorn, E.A.,Rittenhouse, S.,Gwynn, M.N.,Pearson, N.D. (登録日: 2013-06-20, 公開日: 2013-08-07, 最終更新日: 2023-12-20)

• 主引用文献: Miles, T.J.,Hennessy, A.J.,Bax, B.,Brooks, G.,Brown, B.S.,Brown, P.,Cailleau, N.,Chen, D.,Dabbs, S.,Davies, D.T.,Esken, J.M.,Giordano, I.,Hoover, J.L.,Huang, J.,Jones, G.E.,Kusalakumari Sukmar, S.K.,Spitzfaden, C.,Markwell, R.E.,Minthorn, E.A.,Rittenhouse, S.,Gwynn, M.N.,Pearson, N.D.; Novel Hydroxyl Tricyclics (E.G., Gsk966587) as Potent Inhibitors of Bacterial Type Iia Topoisomerases.; Bioorg.Med.Chem.Lett., 23:5437-, 2013; PubMed: 23968823; DOI: 10.1016/J.BMCL.2013.07.013

実験手法

X-RAY DIFFRACTION (2.6 Å)