4BQJ

structure of HSP90 with an inhibitor bound

4BQJ の概要

関連するPDBエントリー4BQG
分子名称HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]-N-ethyl-1,2-oxazole-3-carboxamide (3 entities in total)
機能のキーワードhydrolase
由来する生物種HOMO SAPIENS (HUMAN)
細胞内の位置Cytoplasm  P07900
ポリマー鎖数1
分子量合計26196.26
構造登録者
主引用文献
Brasca, M.G.,Mantegani, S.,Amboldi, N.,Bindi, S.,Caronni, D.,Casale, E.,Ceccarelli, W.,Colombo, N.,De Ponti, A.,Donati, D.,Ermoli, A.,Fachin, G.,Felder, E.R.,Ferguson, R.D.,Fiorelli, C.,Guanci, M.,Isacchi, A.,Pesenti, E.,Polucci, P.,Riceputi, L.,Sola, F.,Visco, C.,Zuccotto, F.,Fogliatto, G.
Discovery of Nms-E973 as Novel, Selective and Potent Inhibitor of Heat Shock Protein 90 (Hsp90).
Bioorg.Med.Chem., 21:7047-, 2013
PubMed: 24100158 (主引用文献が同じPDBエントリー)
DOI: 10.1016/J.BMC.2013.09.018
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.222202.2%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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