4BNM
Crystal structure of S. aureus FabI in complex with NADP and 5-hexyl- 2-(2-methylphenoxy)phenol
Summary for 4BNM
Entry DOI | 10.2210/pdb4bnm/pdb |
Related | 4BNF 4BNG 4BNH 4BNI 4BNJ 4BNK 4BNL 4BNN |
Descriptor | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], 5-HEXYL-2-(2-METHYLPHENOXY)PHENOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, safabi, oxidoreductase |
Biological source | STAPHYLOCOCCUS AUREUS SUBSP. AUREUS |
Total number of polymer chains | 8 |
Total formula weight | 258111.95 |
Authors | Schiebel, J.,Chang, A.,Bommineni, G.R.,Tonge, P.J.,Kisker, C. (deposition date: 2013-05-15, release date: 2013-06-05, Last modification date: 2023-12-20) |
Primary citation | Chang, A.,Schiebel, J.,Yu, W.,Bommineni, G.R.,Pan, P.,Baxter, M.V.,Khanna, A.,Sotriffer, C.A.,Kisker, C.F.,Tonge, P.J. Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex. Biochemistry, 52:4217-, 2013 Cited by PubMed: 23697754DOI: 10.1021/BI400413C PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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