4BNI

Crystal structure of S. aureus FabI in complex with NADP and 2-(2- aminophenoxy)-5-hexylphenol

4BNI の概要

• エントリーDOI: 10.2210/pdb4bni/pdb
• 関連するPDBエントリー: 4BNF 4BNG 4BNH 4BNJ 4BNK 4BNL 4BNM 4BNN
• 分子名称: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], GLUTAMIC ACID, 2-(2-azanylphenoxy)-5-hexyl-phenol, ... (5 entities in total)
• 機能のキーワード: short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, safabi, oxidoreductase
• 由来する生物種: STAPHYLOCOCCUS AUREUS SUBSP. AUREUS
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 258414.11

構造登録者

Schiebel, J.,Chang, A.,Bommineni, G.R.,Tonge, P.J.,Kisker, C. (登録日: 2013-05-15, 公開日: 2013-06-05, 最終更新日: 2023-12-20)

• 主引用文献: Chang, A.,Schiebel, J.,Yu, W.,Bommineni, G.R.,Pan, P.,Baxter, M.V.,Khanna, A.,Sotriffer, C.A.,Kisker, C.F.,Tonge, P.J.; Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the S. Aureus Fabi Enzyme-Product Complex.; Biochemistry, 52:4217-, 2013; PubMed: 23697754; DOI: 10.1021/BI400413C

実験手法

X-RAY DIFFRACTION (2.2 Å)