4BKT

von Hippel Lindau protein:ElonginB:ElonginC complex, in complex with (2S,4R)-N-methyl-1-[2-(3-methyl-1,2-oxazol-5-yl)ethanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide

Summary for 4BKT

• Entry DOI: 10.2210/pdb4bkt/pdb
• Related: 4BKS
• Descriptor: TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR, ... (7 entities in total)
• Functional Keywords: protein transport, ligase, fragment based drug discovery
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus : Q15370 Q15369; Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337
• Total number of polymer chains: 12
• Total formula weight: 167924.57

Authors

Van Molle, I.,Dias, D.M.,Baud, M.,Galdeano, C.,Geraldes, C.F.G.C.,Ciulli, A. (deposition date: 2013-04-29, release date: 2013-11-27, Last modification date: 2017-07-12)

• Primary citation: Dias, D.M.,Van Molle, I.,Baud, M.G.J.,Galdeano, C.,Geraldes, C.F.G.C.,Ciulli, A.; Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein-Protein Interactions?; Acs Med.Chem.Lett., 5:23-, 2014; PubMed: 24436777; DOI: 10.1021/ML400296C

Experimental method

X-RAY DIFFRACTION (2.35 Å)