4BKE

Recombinant human serum albumin with palmitic acid. Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin

4BKE の概要

• エントリーDOI: 10.2210/pdb4bke/pdb
• 分子名称: SERUM ALBUMIN, PALMITIC ACID (3 entities in total)
• 機能のキーワード: transport protein, albumin binding, group epitope mapping, molecular docking
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Secreted: P02768
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 71264.66

構造登録者

Sivertsen, A.,Isaksson, J.,Leiros, H.-K.S.,Svenson, J.,Svendsen, J.-S.,Brandsdal, B.-O. (登録日: 2013-04-24, 公開日: 2014-02-05, 最終更新日: 2024-10-23)

主引用文献

Sivertsen, A.,Isaksson, J.,Leiros, H.S.,Svenson, J.,Svendsen, J.,Brandsdal, B.O.
Synthetic Cationic Antimicrobial Peptides Bind with Their Hydrophobic Parts to Drug Site II of Human Serum Albumin.
Bmc Struct.Biol., 14:4-, 2014

PubMed Abstract: Many biologically active compounds bind to plasma transport proteins, and this binding can be either advantageous or disadvantageous from a drug design perspective. Human serum albumin (HSA) is one of the most important transport proteins in the cardiovascular system due to its great binding capacity and high physiological concentration. HSA has a preference for accommodating neutral lipophilic and acidic drug-like ligands, but is also surprisingly able to bind positively charged peptides. Understanding of how short cationic antimicrobial peptides interact with human serum albumin is of importance for developing such compounds into the clinics.

PubMed: 24456893
DOI: 10.1186/1472-6807-14-4

実験手法

X-RAY DIFFRACTION (2.35 Å)