4BGH
Crystal Structure of CDK2 in complex with pan-CDK Inhibitor
Summary for 4BGH
Entry DOI | 10.2210/pdb4bgh/pdb |
Descriptor | CYCLIN-DEPENDENT KINASE 2, 4-((5-BROMO-4-(PROP-2-YN-1-YLAMINO)PYRIMIDIN-2-YL)AMINO)BENZENESULFONAMIDE (3 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 34378.75 |
Authors | Luecking, U.,Jautelat, R.,Krueger, M.,Brumby, T.,Lienau, P.,Schaefer, M.,Briem, H.,Schulze, J.,Hillisch, A.,Reichel, A.,Siemeister, G. (deposition date: 2013-03-26, release date: 2013-09-04) |
Primary citation | Lucking, U.,Jautelat, R.,Kruger, M.,Brumby, T.,Lienau, P.,Schafer, M.,Briem, H.,Schulze, J.,Hillisch, A.,Reichel, A.,Wengner, A.M.,Siemeister, G. The Lab Oddity Prevails: Discovery of Pan-Cdk Inhibitor (R)- S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-Hydroxy-1-Methylpropyl]Oxy}-5-(Trifluoromethyl)Pyrimidin-2-Yl]Amino}Phenyl)Sulfoximide (Bay 1000394) for the Treatment of Cancer. Chemmedchem, 8:1067-, 2013 Cited by PubMed: 23671017DOI: 10.1002/CMDC.201300096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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