4BE2

PFV intasome with inhibitor XZ-259

4BE2 の概要

• エントリーDOI: 10.2210/pdb4be2/pdb
• 関連するPDBエントリー: 2X6N 2X6S 2X74 2X78 4BAC 4BDY 4BDZ 4BE0 4BE1
• 分子名称: PFV INTEGRASE, 19 NUCLEOTIDE PREPROCESSED PFV DONOR DNA (NON-TRANSFERRED STRAND), 17 NUCLEOTIDE PREPROCESSED PFV DONOR DNA (TRANSFERRED STRAND) *AP*CP*A)-3', ... (9 entities in total)
• 機能のキーワード: transferase-dna complex, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, zinc binding, hhcc motif, viral protein, recombination, inhibitor, recombination-inhibitor-dna complex, transferase/dna
• 由来する生物種: HUMAN SPUMARETROVIRUS; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 101245.40

構造登録者

Hare, S.,Cherepanov, P. (登録日: 2012-10-08, 公開日: 2012-10-31, 最終更新日: 2023-12-20)

• 主引用文献: Metifiot, M.,Maddali, K.,Johnson, B.C.,Hare, S.,Smith, S.J.,Zhao, X.Z.,Marchand, C.,Burke, T.R.,Hughes, S.H.,Cherepanov, P.,Pommier, Y.; Activities, Crystal Structures and Molecular Dynamics of Dihydro-1H-Isoindole Derivatives, Inhibitors of HIV-1 Integrase.; Acs Chem.Biol., 8:209-, 2013; PubMed: 23075516; DOI: 10.1021/CB300471N

実験手法

X-RAY DIFFRACTION (2.38 Å)