4B6G

The Crystal Structure of the Neisserial Esterase D.

4B6G の概要

• エントリーDOI: 10.2210/pdb4b6g/pdb
• 分子名称: PUTATIVE ESTERASE (2 entities in total)
• 機能のキーワード: hydrolase, formaldehyde detoxification, alpha/beta serine hydrolase
• 由来する生物種: NEISSERIA MENINGITIDIS MC58
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64776.39

構造登録者

Counago, R.M.,Kobe, B. (登録日: 2012-08-13, 公開日: 2012-11-14, 最終更新日: 2023-12-20)

主引用文献

Chen, N.H.,Counago, R.M.,Djoko, K.Y.,Jennings, M.P.,Apicella, M.A.,Kobe, B.,McEwan, A.G.
A glutathione-dependent detoxification system is required for formaldehyde resistance and optimal survival of Neisseria meningitidis in biofilms.
Antioxid. Redox Signal., 18:743-755, 2013

PubMed Abstract: The glutathione-dependent AdhC-EstD formaldehyde detoxification system is found in eukaryotes and prokaryotes. It is established that it confers protection against formaldehyde that is produced from environmental sources or methanol metabolism. Thus, its presence in the human host-adapted bacterial pathogen Neisseria meningitidis is intriguing. This work defined the biological function of this system in the meningococcus using phenotypic analyses of mutants linked to biochemical and structural characterization of purified enzymes.

PubMed: 22937752
DOI: 10.1089/ars.2012.4749

実験手法

X-RAY DIFFRACTION (1.4 Å)