4B4Y

crystal structure of the neuroglobin from the photosymbiotic marine acoel Symsagittifera roscoffensis

Summary for 4B4Y

• Entry DOI: 10.2210/pdb4b4y/pdb
• Descriptor: NEUROGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, OXYGEN MOLECULE, ... (4 entities in total)
• Functional Keywords: transport protein, nervous system evolution, globin evolution, cnidarian, metazoan
• Biological source: SYMSAGITTIFERA ROSCOFFENSIS
• Total number of polymer chains: 1
• Total formula weight: 18128.69

Authors

Lechauve, C.,Jager, M.,Laguerre, L.,Kiger, L.,Correc, G.,Leroux, C.,Vinogradov, S.,Czjzek, M.,Marden, M.C.,Bailly, X. (deposition date: 2012-08-01, release date: 2013-01-09, Last modification date: 2024-05-08)

Primary citation

Lechauve, C.,Jager, M.,Laguerre, L.,Kiger, L.,Correc, G.,Leroux, C.,Vinogradov, S.,Czjzek, M.,Marden, M.C.,Bailly, X.
Neuroglobins: Pivotal Proteins Associated with Emerging Neural Systems and Precursors of Metazoan Globin Diversity.
J.Biol.Chem., 288:6957-, 2013

PubMed Abstract: Neuroglobins, previously thought to be restricted to vertebrate neurons, were detected in the brain of a photosymbiotic acoel, Symsagittifera roscoffensis, and in neurosensory cells of the jellyfish Clytia hemisphaerica. For the neuroglobin of S. roscoffensis, a member of a lineage that originated either at the base of the bilateria or of the deuterostome clade, we report the ligand binding properties, crystal structure at 2.3 Å, and brain immunocytochemical pattern. We also describe in situ hybridizations of two neuroglobins specifically expressed in differentiating nematocytes (neurosensory cells) and in statocytes (ciliated mechanosensory cells) of C. hemisphaerica, a member of the early branching animal phylum cnidaria. In silico searches using these neuroglobins as queries revealed the presence of previously unidentified neuroglobin-like sequences in most metazoan lineages. Because neural systems are almost ubiquitous in metazoa, the constitutive expression of neuroglobin-like proteins strongly supports the notion of an intimate association of neuroglobins with the evolution of animal neural systems and hints at the preservation of a vitally important function. Neuroglobins were probably recruited in the first protoneurons in early metazoans from globin precursors. Neuroglobins were identified in choanoflagellates, sponges, and placozoans and were conserved during nervous system evolution. Because the origin of neuroglobins predates the other metazoan globins, it is likely that neuroglobin gene duplication followed by co-option and subfunctionalization led to the emergence of globin families in protostomes and deuterostomes (i.e. convergent evolution).

PubMed: 23288852
DOI: 10.1074/JBC.M112.407601

Experimental method

X-RAY DIFFRACTION (2.3 Å)