4B2V

S64, a spider venom toxin peptide from Sicarius dolichocephalus

4B2V の概要

• エントリーDOI: 10.2210/pdb4b2v/pdb
• 関連するPDBエントリー: 4B2U
• NMR情報: BMRB: 18729
• 分子名称: S64 (1 entity in total)
• 機能のキーワード: toxin, spider venom peptide, ick
• 由来する生物種: SICARIUS DOLICHOCEPHALUS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3570.01

構造登録者

Loening, N.M.,Wilson, Z.N.,Zobel-Thropp, P.A.,Binford, G.J. (登録日: 2012-07-18, 公開日: 2013-01-16, 最終更新日: 2024-11-13)

主引用文献

Loening, N.M.,Wilson, Z.N.,Zobel-Thropp, P.A.,Binford, G.J.
Solution Structures of Two Homologous Venom Peptides from Sicarius Dolichocephalus
Plos One, 8:54401-, 2013

PubMed Abstract: We present solution-state NMR structures for two putative venom peptides from Sicarius dolichocephalus. These peptides were identified from cDNA libraries created from venom gland mRNA and then recombinantly expressed. They are the first structures from any species of Sicarius spiders, and the first peptide structures for any haplogyne spiders. These peptides are homologous to one another, and while they have at most only 20% sequence identity with known venom peptides their structures follow the inhibitor cystine knot motif that has been found in a broad range of venom peptides.

PubMed: 23342149
DOI: 10.1371/JOURNAL.PONE.0054401

実験手法

SOLUTION NMR