4B2U

S67, A spider venom toxin peptide from Sicarius dolichocephalus

Summary for 4B2U

• Entry DOI: 10.2210/pdb4b2u/pdb
• Related: 4B2V
• NMR Information: BMRB: 18600
• Descriptor: S67 (1 entity in total)
• Functional Keywords: toxin, spider venom peptide, ick
• Biological source: SICARIUS DOLICHOCEPHALUS
• Total number of polymer chains: 1
• Total formula weight: 4256.85

Authors

Loening, N.M.,Wilson, Z.N.,Zobel-Thropp, P.A.,Binford, G.J. (deposition date: 2012-07-18, release date: 2013-01-16, Last modification date: 2024-10-16)

Primary citation

Loening, N.M.,Wilson, Z.N.,Zobel-Thropp, P.A.,Binford, G.J.
Solution Structures of Two Homologous Venom Peptides from Sicarius Dolichocephalus.
Plos One, 8:54401-, 2013

PubMed Abstract: We present solution-state NMR structures for two putative venom peptides from Sicarius dolichocephalus. These peptides were identified from cDNA libraries created from venom gland mRNA and then recombinantly expressed. They are the first structures from any species of Sicarius spiders, and the first peptide structures for any haplogyne spiders. These peptides are homologous to one another, and while they have at most only 20% sequence identity with known venom peptides their structures follow the inhibitor cystine knot motif that has been found in a broad range of venom peptides.

PubMed: 23342149
DOI: 10.1371/JOURNAL.PONE.0054401

Experimental method

SOLUTION NMR