4B1J

Structure of human PARG catalytic domain in complex with ADP-HPD

Summary for 4B1J

Entry DOI	10.2210/pdb4b1j/pdb
Related	4A0D 4B1G 4B1H 4B1I
Descriptor	POLY(ADP-RIBOSE) GLYCOHYDROLASE, GLYCEROL, 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, ... (5 entities in total)
Functional Keywords	hydrolase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 1: Nucleus . Isoform 2: Cytoplasm . Isoform 3: Cytoplasm. Isoform 4: Cytoplasm. Isoform 5: Mitochondrion matrix: Q86W56
Total number of polymer chains	1
Total formula weight	61991.03
Authors	Brassington, C.,Ellston, J.,Hassall, G.,Holdgate, G.,McAlister, M.,Overman, R.,Smith, G.,Tucker, J.A.,Watson, M. (deposition date: 2012-07-10, release date: 2012-12-19, Last modification date: 2023-12-20)
Primary citation	Tucker, J.A.,Bennett, N.,Brassington, C.,Durant, S.T.,Hassall, G.,Holdgate, G.,Mcalister, M.,Nissink, J.W.M.,Truman, C.,Watson, M. Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives. Plos One, 7:50889-, 2012 Cited by PubMed: 23251397 DOI: 10.1371/JOURNAL.PONE.0050889 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation