4AUT
Crystal structure of the tuberculosis drug target Decaprenyl- Phosphoryl-beta-D-Ribofuranose-2-oxidoreductase (DprE1) from Mycobacterium smegmatis
Summary for 4AUT
Entry DOI | 10.2210/pdb4aut/pdb |
Descriptor | DECAPRENYL-PHOSPHORYL-BETA-D-RIBOFURANOSE-2-OXIDOREDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total) |
Functional Keywords | oxidoreductase, tuberculosis, benzothiazinone, mycobacteria |
Biological source | MYCOBACTERIUM SMEGMATIS |
Total number of polymer chains | 1 |
Total formula weight | 51976.44 |
Authors | Neres, J.,Pojer, F.,Molteni, E.,Chiarelli, L.R.,Dhar, N.,Boy-Rottger, S.,Buroni, S.,Fullam, E.,Degiacomi, G.,Lucarelli, A.,Read, R.J.,Zanoni, G.,Edmondson, D.E.,De Rossi, E.,Pasca, M.,Riccardi, G.,Mattevi, A.,Dyson, P.J.,Cole, S.T.,Binda, C. (deposition date: 2012-05-21, release date: 2012-09-05, Last modification date: 2023-12-20) |
Primary citation | Neres, J.,Pojer, F.,Molteni, E.,Chiarelli, L.R.,Dhar, N.,Boy-Rottger, S.,Buroni, S.,Fullam, E.,Degiacomi, G.,Lucarelli, A.P.,Read, R.J.,Zanoni, G.,Edmondson, D.E.,De Rossi, E.,Pasca, M.R.,Mckinney, J.D.,Dyson, P.J.,Riccardi, G.,Mattevi, A.,Cole, S.T.,Binda, C. Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium Tuberculosis. Sci. Transl. Med., 4:121-, 2012 Cited by PubMed: 22956199DOI: 10.1126/SCITRANSLMED.3004395 PDB entries with the same primary citation |
Experimental method |
Structure validation
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