4AUT

Crystal structure of the tuberculosis drug target Decaprenyl- Phosphoryl-beta-D-Ribofuranose-2-oxidoreductase (DprE1) from Mycobacterium smegmatis

4AUT の概要

• エントリーDOI: 10.2210/pdb4aut/pdb
• 分子名称: DECAPRENYL-PHOSPHORYL-BETA-D-RIBOFURANOSE-2-OXIDOREDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
• 機能のキーワード: oxidoreductase, tuberculosis, benzothiazinone, mycobacteria
• 由来する生物種: MYCOBACTERIUM SMEGMATIS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51976.44

構造登録者

Neres, J.,Pojer, F.,Molteni, E.,Chiarelli, L.R.,Dhar, N.,Boy-Rottger, S.,Buroni, S.,Fullam, E.,Degiacomi, G.,Lucarelli, A.,Read, R.J.,Zanoni, G.,Edmondson, D.E.,De Rossi, E.,Pasca, M.,Riccardi, G.,Mattevi, A.,Dyson, P.J.,Cole, S.T.,Binda, C. (登録日: 2012-05-21, 公開日: 2012-09-05, 最終更新日: 2023-12-20)

• 主引用文献: Neres, J.,Pojer, F.,Molteni, E.,Chiarelli, L.R.,Dhar, N.,Boy-Rottger, S.,Buroni, S.,Fullam, E.,Degiacomi, G.,Lucarelli, A.P.,Read, R.J.,Zanoni, G.,Edmondson, D.E.,De Rossi, E.,Pasca, M.R.,Mckinney, J.D.,Dyson, P.J.,Riccardi, G.,Mattevi, A.,Cole, S.T.,Binda, C.; Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium Tuberculosis.; Sci. Transl. Med., 4:121-, 2012; PubMed: 22956199; DOI: 10.1126/SCITRANSLMED.3004395

実験手法

X-RAY DIFFRACTION (2.1 Å)