4AQJ

Structure of human S100A7 D24G bound to zinc and calcium

4AQJ の概要

• エントリーDOI: 10.2210/pdb4aqj/pdb
• 関連するPDBエントリー: 1PSR 2PSR 2WND 2WOR 2WOS 3PSR 4AQI
• 分子名称: PROTEIN S100-A7, CALCIUM ION, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: metal binding protein, cancer, inflammation, ef-hand
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: P31151
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12174.57

構造登録者

Murray, J.I.,Tonkin, M.L.,Whiting, A.L.,Peng, F.,Farnell, B.,Hof, F.,Boulanger, M.J. (登録日: 2012-04-17, 公開日: 2012-10-17, 最終更新日: 2026-03-04)

主引用文献

Murray, J.I.,Tonkin, M.L.,Whiting, A.L.,Peng, F.,Farnell, B.,Cullen, J.T.,Hof, F.,Boulanger, M.J.
Structural Characterization of S100A15 Reveals a Novel Zinc Coordination Site Among S100 Proteins and Altered Surface Chemistry with Functional Implications for Receptor Binding.
Bmc Struct.Biol., 12:16-, 2012

PubMed Abstract: S100 proteins are a family of small, EF-hand containing calcium-binding signaling proteins that are implicated in many cancers. While the majority of human S100 proteins share 25-65% sequence similarity, S100A7 and its recently identified paralog, S100A15, display 93% sequence identity. Intriguingly, however, S100A7 and S100A15 serve distinct roles in inflammatory skin disease; S100A7 signals through the receptor for advanced glycation products (RAGE) in a zinc-dependent manner, while S100A15 signals through a yet unidentified G-protein coupled receptor in a zinc-independent manner. Of the seven divergent residues that differentiate S100A7 and S100A15, four cluster in a zinc-binding region and the remaining three localize to a predicted receptor-binding surface.

PubMed: 22747601
DOI: 10.1186/1472-6807-12-16

実験手法

X-RAY DIFFRACTION (1.6 Å)