4ALI

Crystal structure of S. aureus FabI in complex with NADP and triclosan (P1)

Summary for 4ALI

Entry DOI	10.2210/pdb4ali/pdb
Related	4ALJ 4ALK 4ALL 4ALM 4ALN
Descriptor	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRICLOSAN, ... (5 entities in total)
Functional Keywords	oxidoreductase, short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, safabi, fabi
Biological source	STAPHYLOCOCCUS AUREUS
Total number of polymer chains	8
Total formula weight	258447.40
Authors	Schiebel, J.,Chang, A.,Tonge, P.J.,Kisker, C. (deposition date: 2012-03-04, release date: 2012-05-09, Last modification date: 2023-12-20)
Primary citation	Schiebel, J.,Chang, A.,Lu, H.,Baxter, M.V.,Tonge, P.J.,Kisker, C. Staphylococcus Aureus Fabi: Inhibition, Substrate Recognition and Potential Implications for in Vivo Essentiality Structure, 20:802-, 2012 Cited by PubMed: 22579249 DOI: 10.1016/J.STR.2012.03.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation