4AJ4
rat LDHA in complex with 4-((2-allylsulfanyl-1,3-benzothizol-6-yl) amino)-4-oxo-butanoic acid
Summary for 4AJ4
Entry DOI | 10.2210/pdb4aj4/pdb |
Related | 4AJ1 4AJ2 4AJE 4AJH 4AJI 4AJJ 4AJK 4AJL 4AJN 4AJO 4AJP |
Descriptor | L-LACTATE DEHYDROGENASE A CHAIN, MALONATE ION, 4-oxo-4-{[2-(prop-2-en-1-ylsulfanyl)-1,3-benzothiazol-6-yl]amino}butanoic acid, ... (4 entities in total) |
Functional Keywords | oxidoreductase-inhibitor complex, fragment based lead generated inhibitors, oxidoreductase/inhibitor |
Biological source | RATTUS NORVEGICUS (NORWAY RAT) |
Cellular location | Cytoplasm: P04642 |
Total number of polymer chains | 4 |
Total formula weight | 148083.72 |
Authors | Tucker, J.A.,Brassington, C.,Hassall, G.,Vogtherr, M.,Ward, R.,Tart, J.,Davies, G. (deposition date: 2012-02-15, release date: 2012-03-21, Last modification date: 2024-05-01) |
Primary citation | Ward, R.,Brassington, C.,Breeze, A.L.,Caputo, A.,Critchlow, S.,Davies, G.,Goodwin, L.,Hassall, G.,Greenwood, R.,Holdgate, G.,Mrosek, M.,Norman, R.A.,Pearson, S.,Tart, J.,Tucker, J.A.,Vogtherr, M.,Whittaker, D.,Wingfield, J.,Winter, J.,Hudson, K. The Design and Synthesis of Novel Lactate Dehydrogenase a Inhibitors by Fragment-Based Lead Generation J.Med.Chem., 55:3285-, 2012 Cited by PubMed: 22417091DOI: 10.1021/JM201734R PDB entries with the same primary citation |
Experimental method |
Structure validation
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