4AIB

Crystal Structure of Ornithine Decarboxylase from Entamoeba histolytica.

Summary for 4AIB

Entry DOI	10.2210/pdb4aib/pdb
Descriptor	ORNITHINE DECARBOXYLASE (2 entities in total)
Functional Keywords	lyase
Biological source	ENTAMOEBA HISTOLYTICA
Total number of polymer chains	4
Total formula weight	178299.12
Authors	Preeti, P.,Kumar, P.,Tomar, S. (deposition date: 2012-02-09, release date: 2013-01-30, Last modification date: 2023-12-20)
Primary citation	Preeti, P.,Tapas, S.,Kumar, P.,Tomar, S. Structural Insight Into Dfmo Resistant Ornithine Decarboxylase from Entamoeba Histolytica: An Inkling to Adaptive Evolution. Plos One, 8:53397-, 2013 Cited by PubMed Abstract: Polyamine biosynthetic pathway is a validated therapeutic target for large number of infectious diseases including cancer, giardiasis and African sleeping sickness, etc. α-Difluoromethylornithine (DFMO), a potent drug used for the treatment of African sleeping sickness is an irreversible inhibitor of ornithine decarboxylase (ODC), the first rate limiting enzyme of polyamine biosynthesis. The enzyme ODC of E. histolytica (EhODC) has been reported to exhibit resistance towards DFMO. PubMed: 23326423 DOI: 10.1371/JOURNAL.PONE.0053397 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.87 Å)

Structure validation