4AI1

Flo5A showing a heptanuclear gadolinium cluster on its surface after 19 min of soaking

4AI1 の概要

• エントリーDOI: 10.2210/pdb4ai1/pdb
• 関連するPDBエントリー: 2XJP 2XJQ 2XJR 2XJS 2XJT 2XJU 2XJV 4AHW 4AHX 4AHY 4AHZ 4AI0 4AI2 4AI3
• 分子名称: FLOCCULATION PROTEIN FLO5, GADOLINIUM ATOM, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: cell adhesion, adhesin, flocculin
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• 細胞内の位置: Secreted, cell wall: P38894
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31240.03

構造登録者

Veelders, M.,Essen, L.-O. (登録日: 2012-02-07, 公開日: 2012-10-03, 最終更新日: 2024-11-20)

主引用文献

Veelders, M.,Essen, L.-O.
Complex Gadolinium-Oxo Clusters Formed Along Concave Protein Surfaces.
Chembiochem, 13:2187-, 2012

PubMed Abstract: Protein-bound contrast: The unusual observation of a heptanuclear gadolinium-oxo cluster on the surface of the cell-adhesion protein Flo5A establishes the basis for directed incorporation of poly-lanthanide clusters into biomolecules. The observed gadolinium cluster might serve as a paradigm for the design of protein-based MRI contrast agents.

PubMed: 22936626
DOI: 10.1002/CBIC.201200441

実験手法

X-RAY DIFFRACTION (1.8 Å)