4AED

Crystal structure of Human enterovirus 71

Summary for 4AED

Entry DOI	10.2210/pdb4aed/pdb
Descriptor	VP1, VP2, VP3, ... (6 entities in total)
Functional Keywords	virus, picornavirus, capsid, pathogen
Biological source	HUMAN ENTEROVIRUS 71 More
Total number of polymer chains	4
Total formula weight	95002.17
Authors	Plevka, P.,Perera, R.,Kuhn, R.J.,Rossmann, M.G. (deposition date: 2012-01-09, release date: 2012-04-25, Last modification date: 2023-12-20)
Primary citation	Plevka, P.,Perera, R.,Cardosa, J.,Kuhn, R.J.,Rossmann, M.G. Crystal Structure of Human Enterovirus 71. Science, 336:1274-, 2012 Cited by PubMed Abstract: Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the "pocket factor," a small molecule that stabilizes the virus, is partly exposed on the floor of the "canyon." Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket. PubMed: 22383808 DOI: 10.1126/SCIENCE.1218713 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.8 Å)

Structure validation